Skip to main content

How Mesothelioma Is Treated ?

Mesothelioma has many treatment methods.With these methods you can get rid of mesothelioma disease.You will have a hard time and this may make you a little tired.

Other modalities of treatment, such as in cancer types; Surgery, radiotherapy, chemotherapy, immunotherapy, supportive therapy, and combinations of these treatments. However, the combination of choice of treatment and the ideal treatment remains rather unclear due to the absence of the staging system and the documentation of different criteria in each clinical treatment series. The final IMIG cycle aims to enable standardization and common evaluation of these treatment protocols.

Mesothelioma Is Treated
Mesothelioma Is Treated

Radiation Therapy
Since malignant mesothelioma generally tends to retain an entire hemithorax, and therefore the planned radiotherapy is aimed at an entire hemithorax, the sensitivity of the structures such as esophagus, lung and spinal cord in the hemithorax to radiation must be limited. For this reason, usually the total dose given is 4500 cGy or less. Some chemotherapeutic agents, such as doxorubicin, may increase the efficacy of given radiotherapy and the toxicity of the locus (radiosensitization).
Radiotherapy is usually not administered as a primary treatment, either as an adjuvant surgical treatment, or as a symptomatic palliation in tumors that hold the chest wall or mediastinum. Surveillance provided for this purpose is relatively low at 17% for 2 years (32). In general, radiotherapy is a far crying cure for a malignant pleural mesothelioma and the tumor is among the radiotherapy-resistant tumors.

Mesothelioma Radiation Therapy
Mesothelioma Radiation Therapy

Given the Phase II study results of the chemotherapies administered, it can be seen that the response rates are between 15% and 40%. The reason for this discrepancy is the variability of patient selection criteria, the diversity in diagnostic criteria, and the lack of use of CT for evaluation in some studies. Combination use of chemotherapy agents has not been shown to be superior to single drug therapy. In a randomized phase II trial, the response to cisplatin + doxorubicin was reported to be 13% while the response to cisplatin + mitomycin was reported to be 28%, but no significant difference in survival was found between the two treatment regimens (33). With a newer treatment regimen, Byrne and colleagues found a 48% response to cisplatin and gemcitabine in 21 patients in a phase II trial (34). With new drugs that may be more effective, efforts are being made both for single use and for use before and after surgical treatment. Anti-angiogenic treatments are also in progress. (more…)